Perricone MD Review | Can You Trust Their Products?

Who wouldn’t like to go for a brand that promises to offer holistic care to your skin? And that too backed by the success stories of its clinical trials. Perricone MD – a renowned name in the field of skincare and wellness that has still managed to remain on top of its game. But is this brand worth the hype? Do their products work at the cost of some side effects? What do the customers say about their experience with this brand? To know about it all, let’s begin with our Perricone MD reviews.

Perricone MD Reviews

While our skin remains exposed to our unhealthy lifestyle and environment, signs of early aging become frequent. We start taking the help of skin care products to sustain our skin’s health. And this is where Perricone MD, a brand claiming to be our skin’s insurance comes into the picture. But do their products genuinely deliver up to the expectations? Let’s find out!

Perricone MD Reviews | The Ultimate Guide You’re Looking For!

It all began when Dr. Perricone, the mastermind behind this brand, researched how to prevent and reverse the adverse effects of various inflammations. He contended this to be the prime cause of aging and diseases. Thus, launching his Clinical Creations in 1997 began the humble journey of Perricone MD. 

The philosophy behind making Perricone MD is treating yourself from the inside out and outside in. A three-tier approach of following a healthy diet, taking nutritional supplements, and using potent topical skincare is at the heart of this brand.

Perricone MD products come into categories like Skincare, Supplements, No Makeup, Acne Relief, and Regimens. This review is going to cover the bestsellers among them. So without making you wait any further, let’s begin!

Perricone MD Cold Plasma Review

Cold Plasma Plus+ is a collection of high-engined products. It provides targeted facial, eyes, neck, chest, arms, and shins treatments. We’ll review some of its bestsellers. 


This lightweight serum claims to brighten up dull or lackluster skin. It aids in reducing fine lines, dullness, enlarged pores, discoloration, and bumpy texture. Acting as a ‘multivitamin for the skin,’ this product promotes the most visible signs of youthful skin. It absorbs pretty fast on the skin. 

Directions: The brand instructs you to lightly cover your face with 3 to 4 drops of the serum once in the morning and once at night on a cleansed face right before applying the moisturizer.


Key Ingredients: Vitamin C Ester gives a collagen-rich look by minimizing and smoothening your skin’s discolored areas over time. Omega 3,6, and 9 act like the moisture barrier that helps to plump and increase the skin’s radiance. At the same time, Copper Tripeptide rejuvenates the skin by repairing dry skin.

This brand conducted a clinical study on 30 women and a consumer study with 52 women over 28 days. Results showed 100% improvement in fine lines, and 87% of the consumers agreed their skin appeared more radiant. 


  • Cruelty-free and 100% vegan.
  • Free of phthalates, sulfates, parabens, talc, or mineral oil.
  • Fragrance-free.
  •  Lightweight and easy to apply.
  • It begins to show results within a week.
  • Diminishes skin texture and increases firmness.
  • Best suitable for sensitive and dry skin.
Perricone MD Cold Plasma Plus+ Advanced Serum Concentrate, 1 fl Oz
  • COLOR BALANCE - Targets skin’s individual needs to visibly correct discoloration, redness and uneven skin tone.
  • REVITALIZE - A multi-tasking serum concentrate transforms dullness into beautiful, youthful radiance.
  • MOISTURIZE - Makes skin smooth, soft, & supple for a youthful look glowing from the inside out.
  • ENHANCED TEXTURE - Lifts and firms skin’s appearance improving its elasticity and creating an even-textured surface.
  • PROVEN RESULTS - 97% of clinical results showed a significant improvement in pore size.


  • This magic potion is high-priced.
  • Ceteareth-20, a non-ionic compound in this product, makes it unsafe for sensitive skin as it can aggravate skin irritation.


Want that sculpted jawline? This lightweight cream promises to sculpt, firm, and tighten areas around your chin. It also lessens the number of wrinkles and fine lines on the neck. Essential amino acids fight dullness and smoothen the skin. 

Directions: Apply it generously on the jawline and neck areas once in the morning and evening. Gently massage it along the bottom of the neck in circular motions, then use back-and-forth motions under the chin and around the jawline. 

Perricone Md Cold Plasma Sub-D/Neck

Key Ingredients: DMAE (an organic compound naturally produced in the human brain) helps lift saggy skin and support its skin surface by protecting it against environmental aggressors. Peptides fortify the damaged skin, and encapsulated caffeine acts as a firming agent.

In a consumer study with 106 women over 28 days run by the brand, 97% felt the skin around the neck areas to be hydrated. 87% of them noticed smoother skin around the chin and jawline.


  • Cruelty-free.
  • Easy to apply and absorbs fast on the skin.
  • Mitigate fine lines around our neck.
  • It provides rich hydration to our skin.
  • Customers rated a good 4.34/5 rating on the Perricone MD website.
Perricone MD Cold Plasma Sub-DNeck, 2 Fl Oz
  • This item is not a tester
  • Packaging may vary
  • Beauty and personal care product


  • Not fragrance-free, and some customers dislike its medicine-like scent.
  • It comes up costing you dearly.


This versatile eye cream targets and dramatically improves the appearance of dark circles, puffiness, crow’s feet, and fine lines—an outstanding choice for skin care around the eyes.


  1. Gently pat this cream around your eye with the help of your ring finger.
  2. Avoid using it in the eyes.
  3. Apply once in the morning and once at night.

Key Ingredients: Vitamin C Ester helps smooth and brighten the skin. It also boosts the production of collagen. Omegas 3, 6, and 9 shield the moisture of our skin. Copper Tripeptide, the amino acid trio, fights off the environmental aggressors.

Clinical results of this product on 32 women over 28 days showed 100% significant improvement in the appearance of crow’s feet.


  • Lightweight and fast absorbing and thus easy to carry.
  • Fragrance-free and non-greasy.
  • It shows immediate and visible improvements.
  • This eye cream diminishes the bags under your eyes.
Perricone MD Cold Plasma Plus+ Advanced Eye Cream | Lightweight Fast-Absorbing | Targets & improves the appearance of dark circles, puffiness, crow's feet, fine lines & loss of firmness
  • HEALTHY LOOK - Visibly corrects the appearance of dark circles and reduces puffiness.
  • REVITALIZE - Significantly improves vibrancy around the eye area.
  • HYDRATION - Helps repair dry skin reduces crow's feet and fine lines making your skin firmer, smoother and younger-looking.
  • COLOR BALANCE - Brightens and minimizes discoloration over time and increases skin's radiance.
  • NATURAL BARRIERS - Omegas 3, 6 and 9 strengthen skin’s moisture barrier improving its ability to retain water.


  • Some customers found this product resulted in flaky and peeled skin around the eye.
  • It is expensive.


This product is a box full of intense hydration! It offers instant hydration for dry, irritated, and flaking skin. Moreover, it also provides deep nourishment leaving soft, supple, and vibrant skin behind. 

Directions: Massage onto a cleansed face and neck gently upwardly until fully absorbed. You may apply it after your serum. Use it in the morning and the evening.


Key Ingredients: Packed with Peptides to gift you the building blocks of healthy skin. Topical application can improve the adverse effects caused by collagen breakdown, including sagging and wrinkles. Vitamin C Ester helps to brighten up the skin. Vegetable Triglyceride Complex is a solid nutrient-rich blend with phytosterols that boosts skin elasticity.   

A consumer study of 108 women after 28 days showed that 89% of the participants confirmed their skin felt nourished.


  • Non-greasy and easy to apply.
  • Instantly moisturizes the skin.
  • Long-lasting.
  • It gives smooth, even-toned, and healthy skin.
  • Suitable to use in any season.
  • It garnered a whopping 4.69/5 rate in customer reviews, as displayed on the purchase page of Perricone MD.
Perricone MD Cold Plasma Plus+ The Intensive Hydrating Complex, 2 oz. (Pack of 1)
  • Peptides: Fortifying Damaged Skin A chain of amino acids, peptides help visibly improve the look and feel of skin thickness and firmness by supporting the building blocks of healthy, youthful-looking skin. Topical application can help improve the appearance of damage caused by collagen breakdown, including wrinkles and sagging.
  • Vitamin C Ester: Supercharged Brightening & Smoothing A more potent, highly stable and less abrasive form of antioxidant powerhouse vitamin C, Vitamin C Ester gives the appearance of collagen-rich skin by smoothing, brightening and minimizing the look of discoloration over time. Unlike traditional vitamin C, Vitamin C Ester is fat-soluble and easily absorbable for maximum antioxidant benefits.
  • Vegetable Triglyceride Complex: Powerful Hydration A complex of vegetable lipids including jojoba, soybean and olive oil that intensely hydrates, smooths and softens by supporting the skin’s barrier function for supple, healthy-looking skin. This nutrient-rich blend is also packed with phytosterols, which are known to help protect and boost skin’s elasticity.


  • An unpleasant odor had upset a few customers.
  • It is pricey. 

Perricone MD No Makeup Review 

In this skincare collection, the brand affirms that the products help create a natural, “no-makeup” look. This category aims at improving your skincare journey with the touch of colors and infused nutrients.


This unique foundation has skin-improving elements. This foundation serum gives a buildable, semi-matte coverage that, over time, also aids in reducing dark spots and uneven skin tone.


  1. Apply evenly on your face in circular motions.
  2. Build with additional layers for more coverage.
  3. Apply it where coverage is needed the most and blend outwards to create a seamless finish.

Key Ingredients: Neuropeptides (protein-like building blocks) unite surface cells and lessen wrinkles. Bisabol (found in chamomile extract) acts as a skin-brightening antioxidant. And Daisy Flower Extract naturally evens skin tone. 

A clinical study of 31 women over 4 weeks showed 100% improvement in skin texture. 


  • Instantly color corrects and camouflages uneven skin tone.
  • Available in 8 shades to fit all skin complexions.
  • It lessens dark spots.
  • A mineral-based broad spectrum of SPF 20 protects your skin from sun damage. 
  •  Lightweight and fragrance-free.
Perricone MD No Makeup Foundation Serum, Nude
  • Neuropeptides: Uniting Surface Cells to Fight Wrinkles
  • BisaBolol: Skin-Brightening Terpene
  • Daisy FLower Extract: Naturally Evens Skin Tone


  • A few customers had issues with its lightest shade being a bit dark for them.
  • It has a hefty price tag.   


This product gives an instant flush to your cheeks which looks natural and seamless. But it will also make your skin even and bright over time.


  1. Shake well.
  2. Apply 1-3 dots on the apple of the cheeks.
  3. Gently pat while blending upwards towards the hairline.

Key Ingredients: Vitamin C Ester brightens up the skin. Chinese Ginger Plant Extract acts as a natural skin brightener. 


  • It gives a natural and glowy finish.
  • This blush pairs well with light makeup looks.
  • Easy to blend and apply.
  • It helps to improve skin health in the long run.
Perricone MD No Makeup Blush | Lightweight Gel-Cream Blush | Tints cheeks with a natural-looking rosiness and a healthy, youthful glow, Visibly improves the appearance of dullness and discoloration
  • No makeup blush is a gel-cream blush that adds natural-looking rosiness to your cheeks
  • This lightweight formula ensures a blendable, seamless tint that visibly improves skin health
  • This sheer serum is buildable so you can keep adding layers until you get the perfect shade


  • Some with sensitive skin complain of skin burns and red rashes.
  • The color of this blush leaves an unwanted orangish tint on a few complexions.
  • Not water-proof, so it may fade off quickly on folks with extremely oily skin.
  • The cap of this blush is too fragile.
  • A bit pricey. 


This cushiony lipstick is ideal for giving your lips the gift of hydration and a tinge of color. It redefines your lip by adding firmness and smoothness.

Directions: Apply generously and evenly on your lip area and coat it more if needed.

perricone md no makeup lipstick

Key Ingredients:  Contains Neuropeptides to unite skin cells and Hyaluronic Acid to provide all-day hydration. Mineral-Based Sunscreen offers advanced protection from harmful UV rays.

A consumer study of 108 women after 28 days showed that 88% of the participants agreed that their lips felt healthier. 


  • Available in three different shades.
  • A healthy option.
  • It improves the overall appearance of lips.
  • It makes lips supple and reduces wrinkles around them.
Perricone MD No Makeup Lipstick, Rose
  • This color is formulated to align with skin tones and pairs well with the golden shade of no makeup foundation and foundation serum
  • A solid-to-serum lipstick with a sheer wash of natural color and mineral-based broad spectrum SPF 15
  • Formulated with neuropeptides and hyaluronic acid, this lightweight-yet-nourishing formula helps to moisturize, resulting in visibly smoother, plumper lips over time


  • This lipstick comes with an exorbitant price tag.

Perricone MD High Potency Review

The High Potency collection of Perricone MD translates into a range of products that apply ‘signature sciences’ to bring out the ‘tried and true’ results. We’ll be reviewing some of its bestsellers now.


As the name implies, this moisturizer works overnight with three forms of retinol to support the skin’s natural recovery and rejuvenation process. It also hydrates the skin and shields its moisture barrier to achieve healthy skin. 

Directions: Massage it on a cleansed face and neck in the evening using gentle, upward motions. 

Perricone MD High Potency Classics Retinol Recovery Overnight Moisturizer

Key Ingredients: Triple Retinol Blend delivers collagen-rich skin. DMAE helps to shield the skin against drying environmental aggressors. Vegetable Triglyceride Complex gives powerful hydration to our skin. 

93% agreed that their skin felt nourished in the consumer results conducted by the brand.


  • It nourishes the skin with its powerful hydration.
  • Hastens skin-replenishment process.
  • Easy to apply.
  • Easy to carry while traveling.
  • It gives a fresh and bright complexion.
Perricone MD High Potency Classics Retinol Recovery Overnight Moisturizer, 0.5 oz.
  • TRIPLE RETINOL BLEND: Advanced Skin Recovery. A unique blend of encapsulated retinol, retinol ester and phyto-retinol helps deliver the look of collagen-rich skin and visibly reduce fine lines and wrinkles by accelerating surface skin exfoliation and renewal. Naturally derived, this blend features all highly stable forms of retinol for effective delivery and absorption.
  • DMAE: Intensive Firming. Naturally produced by the human brain, topical application of DMAE helps visibly tighten sagging skin over time. Easily and quickly absorbed, it helps visibly plump skin to support skin’s surface and protect against drying environmental aggressors.
  • VEGETABLE TRIGLYCERIDE COMPLEX: Powerful Hydration. A complex of vegetable lipids including jojoba, soybean and olive oil that intensely hydrates, smooths and softens by protecting the skin’s barrier function for supple, healthy-looking skin. This nutrient-rich blend is also packed with phytosterols, which are known to visibly improve skin’s elasticity.


  • It falls on the pricey side. 


This serum will provide instant and deep hydration to your skin. You will be able to see visible plumpness. Add to it the smooth complexion that it leaves afterward.


  1. After cleansing, massage the serum onto your face and neck in a gentle upward motion.
  2. Allow it to get absorbed. You may then follow it up with your moisturizer.
  3. Use it in the morning and evening.

Key Ingredients: Hyaluronic 4+2 complex profoundly hydrates your skin. DMAE intensively firms, and Niacinamide (Vitamin B3) improves uneven skin tone.

In the consumer study of 109 women after 28 days, 91% agreed that their skin felt immediately hydrated. 


  • It shows immediate results.
  • Easy to apply and travel-friendly.
  • This serum promotes the healthy growth of your skin.
Perricone MD High Potency Classics Hyaluronic Intensive Hydrating Serum, 2 oz.
  • Hyaluronic 4 + 2 Complex: Instant & Long-Lasting Hydration. An exclusive technology with 4 forms and 2 natural building blocks of hyaluronic acid (HA) to deeply hydrate for a smoother and plumper-looking complexion. A mix of molecular weights allows HA to penetrate different layers of skin, and since we lose HA in our body with age, topical application supports the skin's natural ability to retain moisture.
  • DMAE: Intensive Firming. Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it helps visibly plump skin to support skin's surface structure and protect against drying environmental aggressors.
  • Niacinamide: Renew & Restore. Also known as vitamin B3, it helps visibly minimize the look of imperfections, improve uneven skin tone and diminish dullness by supporting skin’s moisture barrier. Niacinamide is one of the essential vitamins skin needs to maintain a youthful look.


  • People with sensitive skin may face breakouts.


A day and night serum that will aid the skin to be plump, giving it a bouncy, cushion-like finish. It helps the skin become resilient over time.

Directions: After cleansing your face apply this serum in gentle circular motions. You may then follow it with your moisturizer. Use it in the morning and the evening.

Perricone MD High Potency Classics: Growth Factor Firming & Lifting Serum

Key Ingredients: Polyamine supports the healthy growth of your skin. Eggshell Membrane strengthens the skin’s moisture barrier and improves its elasticity. Encapsulated Retinol accelerates the skin’s renewal process.

In clinical results of the study conducted with 36 women after 56 days, 89% showed improved skin redness. That allowed their skin to appear more radiant and bright.


  • It enhances skin tone and firmness.
  • Successfully delivers a visible and dramatic lifting effect.
  • It starts working within 2-3 days.
  • The brand guarantees both short-term and long-term results. 
Perricone MD High Potency Classics Growth Factor Firming & Lifting Serum, 2 oz.
  • Polyamine Growth Factor: An endogenous molecule utilized by nearly every living thing on Earth, polyamine growth factor improves the feel of skin elasticity and helps promote the look of youthful, collagen-rich and visibly firmer skin by replenishing moisture. Skin produces smaller quantities of growth factors with age, often linked to the most visible signs of aging like fine lines, wrinkles, loss of elasticity and uneven texture.


  • Too expensive.

Perricone MD Vitamin C Ester Brightening Serum

This Vitamin C serum boosts skin radiance instantly. It promises to minimize the appearance of dark spots, prevent discoloration, and dramatically improve the skin’s uneven texture. As a result, it leaves your skin appearing more youthful and luminous. 

Directions: After cleansing, massage the serum onto the face and neck area employing a gentle upward motion. Allow it to get absorbed fully, then follow it with your moisturizer. 

Perricone MD Vitamin C Ester Brightening Serum

Key Ingredients: Includes Vitamin C Ester, a more potent and stable form of the antioxidant-rich vitamin C.

A consumer study with 44 women after 28 days, as shown on their page, displays that 93% agreed that their skin looked clearer.


  • Lightweight and easy to carry.
  • Cruelty-free and 100% vegan.
  • Free from nuts, fish, milk, phthalates, sulfates, parabens, talc, and mineral oil.
  • Reduces fine lines and leaves skin glowing.
Perricone MD Vitamin C Ester Brightening Serum 1 Fl Oz (Pack of 1)
  • EVEN TONE - Targets uneven skin tone promoting more evened skin tone with improved clarity.
  • BRIGHTER COMPLEXION- Delivers a brighter, more radiant-looking complexion.
  • GLOW BOOST - Provides an instant boost of luminosity and glow.
  • ORGANIC HYDRATATION SUPPORT - Contains squalene and rosemary leaf extract to hydrate, visibly reduce fine lines, and tighten the appearance of skin.
  • YOUTHFUL SKIN - Promotes brighter and more youthful looking skin.


  • Due to the compounds used in the product, the scent may be foul sometimes.
  • A few customers with sensitive skin felt a burn after applying his product.
  • It comes with a massive price tag.

Perricone MD Neuropeptide Firming Moisturizer

This advanced technology moisturizer deeply firms and tightens the visible signs of skin sagging. It also aids in correcting imperfections and providing nourishment and hydration to your skin.

Directions: Massage this moisturizer on your cleansed face and neck using a gentle upward motion. Use it in the morning and evening.

Perricone MD Neuropeptide Firming Moisturizer

Key Ingredients: Neuropeptides support the skin’s moisture barrier and fight wrinkles. DMAE helps in lifting the skin areas that are sagging. Hyaluronic Acid takes care of all-day hydration.

The consumer study of 105 women after 28 days showed that 91% of participants confirmed seeing improvement in their skin texture.


  • Cruelty-free and 100% Vegan.
  • This cream has a luxurious and rich consistency.
  • Deeply nourishes and hydrates the skin.
  • Show guaranteed results on many skin types.
  • It promotes healthy and youthful-looking skin.
Perricone MD Neuropeptide Firming Moisturizer 2 oz
  • MOISTURIZING - Delivers deep moisture for plumper and youthful-looking skin.
  • NEURO PROTEIN FORMULA - Formulated with neuropeptides visibly correcting wrinkles, imperfections, and discoloration.
  • LIFTING EFFECT - DMAE Visibly lifts loose, sagging skin and corrects the appearance of wrinkles and imperfections.
  • COLOR BALANCE - Makes skin flawless taking away lines, pigmentation and discoloration.
  • SKIN PROTECTION - Antidote to wrinkles, sagging, dullness, and discoloration, this moisturizer protects skin against drying environmental aggressors.


  • It comes with an exorbitant price tag.

So, this consisted of the gist of Perricone MD Reviews. Let us see what the customers have to say about these products.

Customer Reviews | Perricone MD Reviews

Eva commented, “This changed the game for me. It made my skin more supple and hydrated. Now I feel I know what to purchase from now on!”

Sofia expressed, “My love for this serum is increasing daily. I have sensitive skin, but it works like magic. I will continue using it. So happy.”

Lana asserted, “This instant blush has left my skin burning. Would never recommend this to anyone.”


Kylie remarked, “Yes. It does stand up to my expectations. I applied this intensive hydrating serum at night. And I can still feel my supple skin as I write this.”

Perry declared, “So disappointed! My under-eye skin has been peeling since using this eye cream.‘’

Agatha reflected, “I remember my first use of this lipstick. It’s more like a tint. And I kept on applying it often, for it felt so smooth.”

Perricone MD NO MAKEUP LIPSTICK reviews

FAQs | Perricone MD Reviews 

Where is Perricone MD made?

Perricone MD, an advanced luxury skincare brand, is the brainchild of Dr. Nicholas Perricone. The formulation and production of all their products happen in the United States.

Does Perricone MD really work?

Many customers have found satisfactory results in their journey with its products. They employ scientific technology to reverse aging while formulating the products. The clinical and consumer results speak volumes about the product’s success rate. However, few customers complained of their products showing adverse skin side effects. We suggest you perform a patch test or consult a dermatologist before using any product.  

Perricone MD reviews

What Perricone products should I use?

Perricone MD offers multiple products grouped into different categories. Depending upon your need, you can use their serums, moisturizers, eye cream, or even cosmetics that are all healthy for your skin in the long run. They also have hypoallergenic products suitable for sensitive skin.

Why is Perricone MD so expensive?

This skincare brand found its name after Dr. Perricone, a world-renowned aging expert and nutritionist. Apart from running for over two decades, this classic brand has occupied its top position in people’s hearts and the skincare industry. One of the reasons for its hefty rates may be the high-tech formulation and production of the products.

Is Perricone MD a good brand?

This brand has worked for many in their skincare journey. Many consumers love and prefer to continue using the products. However, a few complaints of the side effects also exist.

Ratings of the brand vary. On Sitejabber, it is 2.4 as of now. On Trustpilot, the brand managed to clinch a rating of 4.0 and, finally, 4.5 on many of its products on its official website. 

Perricone MD reviews

Is Perricone MD safe to use?

Yes! As confirmed by many of its customers, this brand is safe to use. But a few customers complained of side effects as potential skin aggressors were missing on product labels. So ensure to check the product details carefully before buying any product. You can contact them via call or email on their official page to address your queries.

Conclusion | Perricone MD Reviews

Now, it is time to halt our Perricone MD reviews. We showed you all their bestsellers and discussed their pros and cons. Perricone MD has maintained its reputation in the skincare and wellness industries for years. Their products are time-tested and display the best use of the scientific knowledge revolving around aging and its side effects. However, we suggest you skim your favorite Perricone MD product’s ingredients via your dermatologist to ensure a safe buy. And remember to incorporate Dr. Perricone’s philosophy of taking care of yourself in both ways, i.e., inside-out and outside-in.

Did we miss any of your queries or leave any piece of information? Do let us know in the comments below.

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About Debbie Adams

Debbie Adams is a passionate writer and beauty enthusiast who runs her blog where she publishes dupes of luxury items. With over 6 years of experience in the beauty industry, Debbie has gained extensive knowledge of the latest trends, products, and techniques to help her readers achieve their best look yet.

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